DNA Metagenomic Analyzes of Clinical Samples from Monkeypox Virus Infected Individuals

In a recent study posted to the bioRxiv*server, researchers analyzed Monkeypox virus (MPXV) genomic sequences obtained from 18 patients who contracted MPXV infection between June and July 2022. Study: Sequencing of Monkeypox virus from infected patients reveals viral genomes with APOBEC3-like editing, gene inactivation and bacterial agents of skin superinfection. Image Credit: Kateryna Kon/Shutterstock Background … Read more

AI-guided tools pinpoint immune cell booster and protective genetic factor for esophageal cancer

Esophageal adenocarcinoma (EAC) is a cancer that affects the mucus-secreting glands of the lower esophagus; the tube that connects the throat to the stomach. It is the most common form of esophageal cancer and is often preceded by Barrett’s metaplasia (BE), a damaging change in cells lining the esophagus. While the cause of EAC remains … Read more

Does vaccine- or infection-induced immunity protect against infection by specific SARS-CoV-2 variants less well?

In a recent study published in Science Translational Medicineresearchers found that vaccinated people had an increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Beta, Gamma or Delta variants. Study: Increased risk of infection with SARS-CoV-2 Beta, Gamma and Delta variant compared to Alpha variant in vaccinated individuals. Image Credit: Nastasia Photo/Shutterstock … Read more

GenomeBits Representation of SARS-CoV-2 Delta and Omicron Genome Sequences

In a recent study published in PLoS ONEresearchers discovered different genomic features of variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron. Study: GenomeBits insight into ommicron and delta variants of coronavirus pathogen† Image Credit: CROCOTHERY/Shutterstock Understanding SARS-CoV-2, the causative pathogen of the 2019 coronavirus disease (COVID-19) pandemic, is still a challenge. … Read more

Genetic diversity within the host and evolution of the SARS-CoV-2 B.1.517 lineage during chronic infection of an immunocompromised individual

In a recent study posted to the medRxiv* preprint server, researchers examined the intra-host evolution and genetic diversity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.517 variant in an immunosuppressed person with chronic coronavirus disease 2019 (COVID-19). Study: Accelerated SARS-CoV-2 intrahost evolution leading to different genotypes during chronic infection. Image Credit: Ninc Vienna/Shutterstock … Read more