Researchers discover how phage resistance helps emerge dominant strains of Salmonella

Researchers from the Quadram Institute and the University of East Anglia have discovered how resistance has contributed to the emergence of dominant strains of Salmonella. In addition to antimicrobial resistance, resistance to bacteriophages can give these insects a boost, at least in the short term. With the emergence of antimicrobial resistance, new ways to combat … Read more

Researchers develop a new method to map the spatial evolution of cancers

In a recent study published in Natureresearchers developed a genetic clone mapping workflow centered around base-specific on sight sequencing (BaSISS) technology to derive quantitative maps of multiple genetic clones of cancer cells. Study: Spatial genomics maps the structure, nature and evolution of cancer clones. Image credit: Lightspring/Shutterstock Background Cancer or neoplastic cells are dynamic entities … Read more

Vitamin D deficiency causes death, new study finds

Vitamin D deficiency increases mortality risk and increasing levels may actually lower the risk slightly, researchers found who studied data from the UK Biobank. They used a Mendelian randomization approach, which uses genetic variants as “proxy indicators” for external factors that affect vitamin D levels, such as sun exposure or dietary intake. It allows analysis … Read more

Multiomics analysis identifies immunobiomarkers for COVID-19 severity in outpatients

In a recent study published in the journal eLiferesearchers demonstrated the utility of machine learning models in identifying early immune signatures, which could reliably predict clinical and immunologic outcomes in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected outpatients. Study: Early immune markers of clinical, virological and immunological outcomes in patients with COVID-19: a multi-omics study. … Read more

‘U-shaped’ relationship between bipolar risk and parental age

VIENNA — Individuals born to younger or older parents are at increased risk of developing bipolar disorder, new research suggests. Results from a meta-analysis of more than 210,000 patients with bipolar disorder and more than 13 million healthy individuals showed that children born to mothers under the age of 20 had a 23% increased risk … Read more

Beckman Coulter Life Sciences Invests in the Next Generation of Researchers and Announces Call for Grant Applications

Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, announces its continued commitment to the next generation of researchers and scientists with a call for registration for its SPRI grants for genomic research. To reinforce its commitment to delivering streamlined genomic workflow solutions, the company will award up to eight grants in … Read more

New machine learning tool discovers mutational signature linking bladder cancer to smoking

Researchers at the University of California at San Diego have discovered for the first time a pattern of DNA mutations that links bladder cancer to tobacco smoking. The discovery was made possible thanks to a powerful new machine learning tool the team developed to find patterns of mutations caused by carcinogens and other DNA-altering processes. … Read more

Azerbaijan Thalassemia Center and BGI collaborate to improve thalassemia screening in Azerbaijan

at 6e In September 2022, the Azerbaijan Thalassemia Center and BGI held a virtual signing ceremony to seal a cooperation agreement. The partnership aims to improve thalassemia screening in Azerbaijan through genetic engineering. In early 2021, on the occasion of the announcement “Prevention and Control of Global Hemoglobinopathies”, the BGI Poverty Prevention and Control Panel … Read more

Circadian rhythm disturbance is shared by wide range of mental illnesses, study finds

Anxiety, autism, schizophrenia and Tourette’s syndrome each have their own distinctive features, but one factor bridging these and most other mental disorders is a disruption in the circadian rhythm, according to a team of researchers in the field of mental health. neuroscience, pharmaceutical science, and computer science at the University of California, Irvine. In a … Read more

Study Provides Comprehensive View of Genomics of All Childhood ALL Subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL). The St. Jude Children’s Research Hospital study is the first to provide a comprehensive overview of the genomics of all subtypes of ALL. The work serves as a fundamental guide for physicians and scientists to … Read more