Researchers discover how phage resistance helps emerge dominant strains of Salmonella

Researchers from the Quadram Institute and the University of East Anglia have discovered how resistance has contributed to the emergence of dominant strains of Salmonella. In addition to antimicrobial resistance, resistance to bacteriophages can give these insects a boost, at least in the short term. With the emergence of antimicrobial resistance, new ways to combat … Read more

The vaginal microbiome through the lens of systems biology

The human organism is a complex ecosystem of coexisting microbiomes, including those in the gut, skin and vagina in women. These play a crucial role in health and disease. However, there is still much to learn about them. A new article recently published online in Trends in microbiology magazine discusses the systems biology approach to … Read more

Rutgers scientists are developing a new approach to effectively stop viral infections

Rutgers scientists have developed a new approach to stopping viral infections: a so-called live attenuated, replication-defective DNA virus vaccine that uses a compound known as centanamycin to generate an altered virus for vaccine development. The method was tested to produce a weakened or “weakened” version of a mouse cytomegalovirus, a common virus, that has been … Read more

Scientists investigate isolation of bat sarbecovirus in Japan

In a recent study published in Emerging infectious diseasesresearchers conducted bat sarbecovirus isolation experiments using Horned Rhinolophus bats from different regions in Japan that were phylogenetically situated in the same cluster of viruses associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Isolation of Bat Sarbecoviruses, Japan. Image Credit: Independent Birds/Shutterstock Highly pathogenic human … Read more

Researchers develop a new method to map the spatial evolution of cancers

In a recent study published in Natureresearchers developed a genetic clone mapping workflow centered around base-specific on sight sequencing (BaSISS) technology to derive quantitative maps of multiple genetic clones of cancer cells. Study: Spatial genomics maps the structure, nature and evolution of cancer clones. Image credit: Lightspring/Shutterstock Background Cancer or neoplastic cells are dynamic entities … Read more

Research shows the added value of genetic information in measuring the risk of hereditary diseases

A new study from the University of Helsinki demonstrates the added value of genetic information in measuring hereditary disease risk, in addition to the commonly used family history assessment. Doctors use a lot of family history to assess an individual’s risk of developing common diseases, such as coronary heart disease, diabetes, and cancers. In recent … Read more

Hybrid immunity to vaccination and Omicron BA.1 or BA.5 breakthrough infections shows cross-reactive activity against BA.2.75

In a recent study published in Eurosurveillanceresearchers from Israel measured the neutralizing antibody titers against the wild-type strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the SARS-CoV-2 Omicron subvariants BA.1, BA.2, BA.2.75 and BA. 5 in health care workers who were fully vaccinated with three doses of the Comirnaty vaccine and who experienced … Read more

Rare variants of type I IFN immunity genes may underlie life-threatening COVID-19

In a recent study posted to the medRxiv* preprint server, researchers assessed whether loss-of-function (pLOF) variants of type I interferon (IFN) immunity genes are associated with life-threatening coronavirus disease 2019 (COVID-19). Study: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19. Image Credit: Billion Photos Background Critical COVID-19 can … Read more

COVID-19 and the intestines

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the 2019 coronavirus disease (COVID-19), has so far infected more than 625 million people and caused more than 6.5 million deaths. While COVID-19 is primarily a respiratory disease, it can also lead to neurological and digestive symptoms. a new nutrients study examines the … Read more

Dog Ownership During Childhood May Reduce Risk of Persistent Wheezing

In a recent study published in the Journal of Allergy and Clinical ImmunologyResearchers examined the gene-environment (GxE) interactions between childhood pet ownership and the 17q12-21 (asthma risk) locus related to wheezing. Study: Dog ownership in childhood is protective against persistent wheezing in carriers of 17q21 asthma risk. Image Credit: Nina Buday/Shutterstock The heritability of asthma … Read more