New machine learning tool discovers mutational signature linking bladder cancer to smoking

Researchers at the University of California at San Diego have discovered for the first time a pattern of DNA mutations that links bladder cancer to tobacco smoking. The discovery was made possible thanks to a powerful new machine learning tool the team developed to find patterns of mutations caused by carcinogens and other DNA-altering processes. … Read more

AI-guided tools pinpoint immune cell booster and protective genetic factor for esophageal cancer

Esophageal adenocarcinoma (EAC) is a cancer that affects the mucus-secreting glands of the lower esophagus; the tube that connects the throat to the stomach. It is the most common form of esophageal cancer and is often preceded by Barrett’s metaplasia (BE), a damaging change in cells lining the esophagus. While the cause of EAC remains … Read more

Medulloblastomas arise much earlier in pregnancy than previously thought and can be prevented

According to a new international study, an aggressive type of brain tumor in children, medulloblastoma, exists in a premalignant form at birth after initially developing during the first or second trimester of pregnancy. Since medulloblastomas are typically present during childhood, around age seven, the team’s discovery is the first indication that there could be a … Read more

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumor cells evade immune therapy by generating unique, temporary cell-in-cell structures, leaving the inner cells intact and able to revert to individual tumor cells. These findings, published today in eLife, offer a new theory of how tumor cells avoid destruction by the immune system. They may also inform the development of … Read more

Azerbaijan Thalassemia Center and BGI collaborate to improve thalassemia screening in Azerbaijan

at 6e In September 2022, the Azerbaijan Thalassemia Center and BGI held a virtual signing ceremony to seal a cooperation agreement. The partnership aims to improve thalassemia screening in Azerbaijan through genetic engineering. In early 2021, on the occasion of the announcement “Prevention and Control of Global Hemoglobinopathies”, the BGI Poverty Prevention and Control Panel … Read more

The brain and fat communicate directly

With increasing rates of obesity and related metabolic diseases reported worldwide, researchers have struggled to understand the functional status of adipose tissue in the body in relation to overall energy homeostasis. a new Nature study investigates the sensory innervation of fat cells in subcutaneous fat deposits, delineating the anatomical and functional effects of interference with … Read more

A mother’s diet during pregnancy is linked to her child’s food preferences

Nutrition during pregnancy is an important factor in determining the health of the developing fetus and newborn after birth. However, little is known about how diet quality during pregnancy affects the development of food-related traits in the offspring. A recent pull Journal study examines relationship between maternal diet quality during pregnancy and offspring’s appetite-stimulating properties … Read more

Study Provides Comprehensive View of Genomics of All Childhood ALL Subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL). The St. Jude Children’s Research Hospital study is the first to provide a comprehensive overview of the genomics of all subtypes of ALL. The work serves as a fundamental guide for physicians and scientists to … Read more

Disrupting a virus’s genome packaging could stop replication, study finds

Like savvy international travelers, viruses know exactly how to pack. With the genetic instructions for the next generation folded exactly like this, nestled in a custom outer layer dotted with cell-grabbing proteins, these tiny invaders search for new digs on the reg. When they find them, they get to work. Each newly infected cell quickly … Read more

A practical guide to the diagnosis, prevention and treatment of monkeypox

Countries around the world continue to struggle to contain the coronavirus disease 2019 (COVID-19), despite developing effective mitigation strategies to reduce the spread of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). . Recently, thousands of cases of monkey pox have been recorded in non-endemic countries. Studies are underway to determine the source … Read more