Researchers discover how phage resistance helps emerge dominant strains of Salmonella

Researchers from the Quadram Institute and the University of East Anglia have discovered how resistance has contributed to the emergence of dominant strains of Salmonella. In addition to antimicrobial resistance, resistance to bacteriophages can give these insects a boost, at least in the short term. With the emergence of antimicrobial resistance, new ways to combat … Read more

Researchers discover new therapeutic vulnerability in breast cancer that is resistant to hormone therapy

For patients with estrogen receptor (ER) positive breast cancer, the development of the so-called Y537S mutation indicates that their disease has taken an aggressive course and may be becoming resistant to endocrine therapy. Now a preclinical study, led by researchers at UT Southwestern Medical Center, suggests that a class of new drugs already in clinical … Read more

Research points to an underexposed aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer’s disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of increasing brain tissue damage. Toxic clusters of proteins first concentrate in the temporal lobes of the brain -; the memory area -; before spreading to parts of the brain important for thinking … Read more

Hemagglutinin strain immunogens may hold the key to broad protection against influenza A viruses

In a recent article published in Immunityresearchers suggested that vaccines targeting the immunosubdominant but conserved hemagglutinin (HA) strain could elicit broadly neutralizing antibodies (bnAbs) against influenza A viruses. Study: Co-immunization with hemagglutinin strain immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses. Image credit: pinkeyes/Shutterstock Background Influenza viruses are highly contagious respiratory … Read more

Circadian disruption causes weight gain through changes in gut microbiota

In a recent study published in the journal Molecular Metabolismresearchers examined the impact of environmental and genetic perturbations of the circadian rhythms on peripheral circadian clock synchronization and microbiomoscillations in the gastrointestinal tract. Study: Original article Genetic and ecological circadian disruption cause weight gain through changes in the gut microbiome. Image Credit: Alpha Tauri 3D … Read more

Study expands population of breast cancer patients who could benefit from PARP inhibitors

A drug approved for the treatment of breast cancer patients with mutations in the BRCA1 or BRCA2 genes can also benefit people with other genetic mutations. UT Southwestern researchers reported in the journal Nature Cancer that talazoparib successfully treated tumors of breast cancer patients with mutations in the PALB2 gene. Patients with this mutation would … Read more

Groundbreaking gene-editing technique can repair defective T cells in patients with CTLA-4 insufficiency

A flaw in cells that make up an important part of the immune system can be repaired with a breakthrough gene-editing technique, according to new research shown in human cells and mice, led by UCL scientists. Researchers say the study, published in Science Translational Medicinecould lead to new treatments for a rare disease of the … Read more

Rare variants of type I IFN immunity genes may underlie life-threatening COVID-19

In a recent study posted to the medRxiv* preprint server, researchers assessed whether loss-of-function (pLOF) variants of type I interferon (IFN) immunity genes are associated with life-threatening coronavirus disease 2019 (COVID-19). Study: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19. Image Credit: Billion Photos Background Critical COVID-19 can … Read more

In utero, exposure to flame retardants leads to altered brain development in newborn rats

A new study from North Carolina State University shows that in utero exposure to the flame-retardant FireMaster┬« 550 (FM 550), or its individual brominated (BFR) or organophosphate ester (OPFR) components, resulted in altered brain development in newborn rats. The effects – particularly evidence of mitochondrial disruption and dysregulated choline and triglyceride levels in brain tissue … Read more

Dog Ownership During Childhood May Reduce Risk of Persistent Wheezing

In a recent study published in the Journal of Allergy and Clinical ImmunologyResearchers examined the gene-environment (GxE) interactions between childhood pet ownership and the 17q12-21 (asthma risk) locus related to wheezing. Study: Dog ownership in childhood is protective against persistent wheezing in carriers of 17q21 asthma risk. Image Credit: Nina Buday/Shutterstock The heritability of asthma … Read more