Research reveals the existence of a hidden ”pocket” on the surface of the main SARS-CoV-2 protein

With the continued emergence of new variants and the risk of new virus strains, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge. Currently, the proteins located on the surface of the virus and/or involved in its replication are the preferred therapeutic targets, such as the Spike protein targeted by vaccines. … Read more

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

In a recent study published in Retrovirologyresearchers assessed the effectiveness of SARS-CoV (Severe Acute Respiratory Syndrome) and SARS-CoV-2 envelope (E) proteins against human immunodeficiency virus (HIV)-1. Study: SARS-CoV-2 and SARS-CoV envelope proteins potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1). Image credit: Corona Borealis Studio/Shutterstock Background Viroporins are ion channels expressed by … Read more

Diet change may be a key to improving colon cancer treatment

A change in diet may be key to improving colon cancer treatment, finds a new study from the University of Michigan Rogel Cancer Center. Cancer cells need nutrients to survive and grow. One of the most important nutrient-sensing molecules in a cell is called mTORC1. Often referred to as a master regulator of cell growth, … Read more

Researchers discover new therapeutic vulnerability in breast cancer that is resistant to hormone therapy

For patients with estrogen receptor (ER) positive breast cancer, the development of the so-called Y537S mutation indicates that their disease has taken an aggressive course and may be becoming resistant to endocrine therapy. Now a preclinical study, led by researchers at UT Southwestern Medical Center, suggests that a class of new drugs already in clinical … Read more

Scientists investigate isolation of bat sarbecovirus in Japan

In a recent study published in Emerging infectious diseasesresearchers conducted bat sarbecovirus isolation experiments using Horned Rhinolophus bats from different regions in Japan that were phylogenetically situated in the same cluster of viruses associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Isolation of Bat Sarbecoviruses, Japan. Image Credit: Independent Birds/Shutterstock Highly pathogenic human … Read more

Research points to an underexposed aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer’s disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of increasing brain tissue damage. Toxic clusters of proteins first concentrate in the temporal lobes of the brain -; the memory area -; before spreading to parts of the brain important for thinking … Read more

SARS-CoV-2 antibodies persist in breast milk after two and three COVID-19 vaccine doses

The World Health Organization (WHO) recommends that babies be breastfed for at least the first six months of life and that breastfeeding be continued for two years or more, along with the gradual introduction of complementary foods. Study: Milk antibody response after third dose of COVID-19 mRNA vaccine and SARS-CoV-2 breakthrough infection and implications for … Read more

Research findings may bolster the effectiveness of immune checkpoint therapy

Immune checkpoint inhibitors like Keytruda and Opdivo work by unleashing the immune system’s T cells to attack tumor cells. Their introduction ten years ago represented a major advancement in cancer therapy, but only 10% to 30% of treated patients experience long-term improvement. In an article published online today in The Journal of Clinical Research (JCI), … Read more

Copper and copper binding proteins may be potential targets for cancer treatment

In order for cancer cells to grow and spread throughout the human body, they need proteins that bind copper ions. New research into how cancer-related proteins bind the metal and how they interact with other proteins opens up potential new targets for drugs in the fight against cancer. Human cells require small amounts of the … Read more

Nutritional interventions targeting key oxidative process may improve motivation

In life, motivation can be the difference between success and failure, goal setting and aimlessness, well-being and unhappiness. And yet, getting and staying motivated is often the most difficult step, a problem that has given rise to much research. A very small part of that research has looked at the question of metabolism. Do … Read more