Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study was recently published in the journal Food and Chemical Toxicology. Study: Lucidic acid A inhibits binding of the hACE2 receptor with spike protein … Read more

How the gut microbiome can influence the severity of COVID-19

As of September 27, 2022, the 2019 coronavirus disease (COVID-19) is responsible for more than 6.5 million deaths worldwide. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 was remarkably unpredictable in its clinical severity. As a result, many efforts have been made to determine the factors that increase an individual’s risk of severe … Read more

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cell models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia investigated the molecular mechanisms of the pulmonary and cardiac complications caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using human stem cell-derived heart and lung cells. Study: Parallel use of pluripotent lung and heart models of human stem cells … Read more

New machine learning tool discovers mutational signature linking bladder cancer to smoking

Researchers at the University of California at San Diego have discovered for the first time a pattern of DNA mutations that links bladder cancer to tobacco smoking. The discovery was made possible thanks to a powerful new machine learning tool the team developed to find patterns of mutations caused by carcinogens and other DNA-altering processes. … Read more

DNA nets effectively target the spike protein and detect the COVID-19 virus at very low levels

Tiny nets woven from strands of DNA can entangle the spike protein of the virus that causes COVID-19, illuminating the virus for a quick but sensitive diagnostic test — as well as preventing the virus from infecting cells, causing a new possible route to antiviral drugs is opened. treatment, according to a new study. Researchers … Read more

AI-guided tools pinpoint immune cell booster and protective genetic factor for esophageal cancer

Esophageal adenocarcinoma (EAC) is a cancer that affects the mucus-secreting glands of the lower esophagus; the tube that connects the throat to the stomach. It is the most common form of esophageal cancer and is often preceded by Barrett’s metaplasia (BE), a damaging change in cells lining the esophagus. While the cause of EAC remains … Read more

Medulloblastomas arise much earlier in pregnancy than previously thought and can be prevented

According to a new international study, an aggressive type of brain tumor in children, medulloblastoma, exists in a premalignant form at birth after initially developing during the first or second trimester of pregnancy. Since medulloblastomas are typically present during childhood, around age seven, the team’s discovery is the first indication that there could be a … Read more

Novel antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

In a recent study published in PLoS pathogensresearchers described a novel antiviral mechanism of action for an FDA (food and drug administration) approved thiopurine known as 6-thioguanine (6-TG). Study: Thiopurins inhibit the processing and uptake of the coronavirus Spike protein in progeny virions. Image Credit: Bacsica/Shutterstock Background The pandemic of severe acute respiratory syndrome coronavirus … Read more

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumor cells evade immune therapy by generating unique, temporary cell-in-cell structures, leaving the inner cells intact and able to revert to individual tumor cells. These findings, published today in eLife, offer a new theory of how tumor cells avoid destruction by the immune system. They may also inform the development of … Read more

New insights into how the circadian clock can promote healing after traumatic brain injury

A type of brain cell that can self-renew is regulated by circadian rhythms, providing important insights into how the body’s internal clock may promote healing after traumatic brain injury (TBI), according to new research from Children’s National Hospital. Released in the last issue of eNeuro, the findings open new avenues of research for future TBI … Read more